𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantioselective Addition of Organozinc Reagents to Aldehydes Catalyzed by 3,3′-Bis(diphenylphosphinoyl)-BINOL

✍ Scribed by Manabu Hatano; Takashi Miyamoto; Kazuaki Ishihara

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
265 KB
Volume
347
Category
Article
ISSN
1615-4150

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The enantioselective addition of organozinc reagents to aromatic and aliphatic aldehydes 1 gives secondary alcohols 2 with excellent enantioselectivities in high yields through the catalytic use of (R)‐3,3′‐bis(diphenylphosphinoyl)‐BINOL (3) or (R)‐3,3′‐bis(diphenylthiophosphinoyl)‐BINOL (4) without Ti(IV) complexes. The coordination of the O or S atom of a (thio)phosphinoyl group bearing a BINOL backbone to organozinc reagents can efficiently increase the nucleophilicity of the organozinc reagents.

📜 SIMILAR VOLUMES

ChemInform Abstract: Enantioselective Ad
ChemInform Abstract: Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by 3,3′-Bis(2-oxazolyl)-1,1′-bi-2-naphthol (BINOL-Box) Ligands Derived from 1,1′-Bi-2-naphthol.
✍ Hidehiko Kodama; Junji Ito; Aiichiro Nagaki; Tetsuo Ohta; Isao Furukawa 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 35 KB 👁 3 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v