Catalytic Asymmetric Total Syntheses of Quinine and Quinidine
โ Scribed by Raheem, Izzat T.; Goodman, Steven N.; Jacobsen, Eric N.
- Book ID
- 111937095
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 61 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Quinine and quinidine were synthesized by a highly enantio-and stereoselective approach starting from a proline-catalyzed asymmetric cycloaldolization of benzyl bis(2-formylethyl)carbamate which gave a 70:30 mixture of (3R,4R)-N-Cbz-3-hydroxymethyl-4-hydroxypiperidine (96% ee) and its 4S-epimer (92%
The first in a new series, this book provides chemists an effective, much-needed way to stay abreast of recent developments in organic synthesis. The 103 articles review the leading synthetic procedures developed from 2003 - 2005, discussing their significance and their applications. More than 100 r