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Catalytic Asymmetric Syntheses of α-Amino and α-Hydroxyl Acid Derivatives

✍ Scribed by Han, Xiaojun; Jiang, Xiang-Jun; Civiello, Rita L.; Degnan, Andrew P.; Chaturvedula, Prasad V.; Macor, John E.; Dubowchik, Gene M.


Book ID
126452176
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
154 KB
Volume
74
Category
Article
ISSN
0022-3263

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Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the