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Scaleable catalytic asymmetric Strecker syntheses of unnatural α-amino acids

✍ Scribed by Zuend, Stephan J.; Coughlin, Matthew P.; Lalonde, Mathieu P.; Jacobsen, Eric N.


Book ID
109898488
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
437 KB
Volume
461
Category
Article
ISSN
0028-0836

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Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the