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Catalytic activation of trichlorosilane for efficient and stereoselective reduction of ketones

✍ Scribed by Fumiaki Iwasaki; Osamu Onomura; Katsuhiko Mishima; Toshihide Maki; Yoshihiro Matsumura

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
262 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Some kinds of N-formyl cyclic amine derivatives were found to be effective activators for trichlorosilane to reduce ketones. Namely, a catalytic amount of these activators were sufficient to complete the reduction of ketones with trichlorosilane, and the reduction of ketones by trichlorosilane with optically active activators gave enantiomerically enriched sec-alcohols in some extent of optical yields (up to 51% ee).

πŸ“œ SIMILAR VOLUMES

First chemo- and stereoselective reducti
First chemo- and stereoselective reduction of imines using trichlorosilane activated with N-formylpyrrolidine derivatives
✍ Fumiaki Iwasaki; Osamu Onomura; Katsuhiko Mishima; Takefumi Kanematsu; Toshihide πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 63 KB

Trichlorosilane activated with N-formylpyrrolidine derivatives was found to be an effective reagent for reduction of imines to amines. The reagent showed much higher selectivity toward imino groups than carbonyl groups. The reduction of imines using trichlorosilane activated with optically active N-