Catalyst Free Indirect Friedländer Synthesis of Substituted Quinolines from Alcohols in PEG-400
✍ Scribed by Fang-Wen Wu; Rei-Sheu Hou; Huey-Min Wang; Iou-Jiun Kang; Ling-Ching Chen
- Book ID
- 112120309
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2012
- Tongue
- English
- Weight
- 531 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-4536
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📜 SIMILAR VOLUMES
Poly-substituted quinolines were synthesized in the presence of a catalytic amount of dodecylphosphonic acid (DPA) in aqueous media and solvent-free conditions. The reactions proceed very well under relatively mild conditions, and DPA can be recycled.
## Abstract A rapid and an efficient method for the preparation of a variety of substituted quinolines has been developed through the reactions of __o__‐aminoarylketones with carbonyl compounds containing a reactive α‐methylene moiety in the presence of molten [Et~3~NH][HSO~4~] under solvent‐free c