Catabolism of 6-deoxy-6-fluoro ascorbic acid (F-ASA) in the lens
β Scribed by Makoto Satake; Janusz Madaj; Barbara Dmochovska; Yoko Nishikawa; Peter L Rinaldi; Vincent M Monnier
- Book ID
- 117550722
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 36 KB
- Volume
- 1245
- Category
- Article
- ISSN
- 0531-5131
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π SIMILAR VOLUMES
A one-pot synthesis of 6-deoxy-6-[18F]fluoro-L-ascorbic acid (18F-DFA) has been developed via nucleophilic displacement of a cyclic sulfate with no-carrier-added [18F]fluoride ion. Isolated radiochemical yields of around 15% were obtained with radiochemical purity of over 99% after overall synthesis
## Abstract An ascorbate analog labeled with iodineβ131, 6βdeoxyβ 6β[^131^I]iodoβLβascorbic acid was prepared for evaluation as an __in vivo__ tracer of Lβascorbic acid. The noβcarrierβadded radiosynthesis was conducted by nucleophilic bromineβiodine exchange between the brominated precursor and so