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Positron-labeled antioxidant 6-deoxy-6-[18F]fluoro-l-ascorbic acid: Increased uptake in transient global ischemic rat brain

✍ Scribed by Fumihiko Yamamoto; Shigenobu Shibata; Shigenori Watanabe; Kouji Masuda; Minoru Maeda

Book ID: 116172138
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 947 KB
Volume: 23
Category: Article
ISSN: 0969-8051
DOI: 10.1016/0969-8051(96)00025-x

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Positron labeled antioxidants: Synthesis

Positron labeled antioxidants: Synthesis and tissue biodistribution of 6-deoxy-6-[18F]fluoro-l-ascorbic acid

✍ Fumihiko Yamamoto; Shigeki Sasaki; Minoru Maeda 📂 Article 📅 1992 🏛 Elsevier Science ⚖ 771 KB

A one-pot synthesis of 6-deoxy-6-[18F]fluoro-L-ascorbic acid (18F-DFA) has been developed via nucleophilic displacement of a cyclic sulfate with no-carrier-added [18F]fluoride ion. Isolated radiochemical yields of around 15% were obtained with radiochemical purity of over 99% after overall synthesis