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Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C

โœ Scribed by Denning, M F; Wang, Y; Tibudan, S; Alkan, S; Nickoloff, B J; Qin, J-Z


Book ID
110016284
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
459 KB
Volume
9
Category
Article
ISSN
1350-9047

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## Abstract Celecoxib is a potent nonsteroid antiinflammatory drug (NSAID) that has shown great promise in cancer chemoprevention and treatment. The tumor suppression activity of celecoxib and other NSAIDs have been related to the induction of apoptosis in many cancer cell lines and animal models.