Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells

2-deoxyglucose inhibits chemotheapeutic

2-deoxyglucose inhibits chemotheapeutic drug-induced apoptosis in human monocytic leukemia U937 cells ith inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation

✍ Naomi Haga; Mikihiko Naito; Hiroyuki Seimiya; Akihiro Tomida; Jian Dong; Takashi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB 👁 2 views

Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind