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Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

✍ Scribed by Demetrius M. Maraganore; Matthew J. Farrer; Timothy G. Lesnick; Mariza De Andrade; James H. Bower; Dena Hernandez; John A. Hardy; Walter A. Rocca

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
71 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We conducted a case‐control study of the α‐synuclein–interacting protein gene (SNCAIP, also known as synphilin‐1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α‐synuclein gene (SNCA) or the parkin (PARK2) gene. © 2003 Movement Disorder Society

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