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Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide

✍ Scribed by Christian Brander; Tony Wyss-Coray; Davide Mauri; Florence Bettens; Werner J. Pichler


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
795 KB
Volume
23
Category
Article
ISSN
0014-2980

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The proteasome is a major enzyme that cleaves proteins for antigen presentation. Cleaved peptides traffic to the cell surface, where they are presented in the context of major histocompatibility complex (MHC) class I. Recognition of these complexes by cytotoxic T lymphocytes is crucial for eliminati