The proteasome is a major enzyme that cleaves proteins for antigen presentation. Cleaved peptides traffic to the cell surface, where they are presented in the context of major histocompatibility complex (MHC) class I. Recognition of these complexes by cytotoxic T lymphocytes is crucial for eliminati
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy
✍ Scribed by Falk Nimmerjahn; Slavoljub Milosevic; Uta Behrends; Elizabeth M. Jaffee; Drew M. Pardoll; Georg W. Bornkamm; Josef Mautner
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 269 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-2980
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Molecules encoded by the major histocompatibility complex (MHC) are polymorphic integral membrane proteins adapted to the presentation of peptide fragments of foreign antigens to antigen-specific T-cells. The diversity of infectious agents to which an immune response must be mounted poses a unique p
We studied major histocompatibility complex class II-dependent presentation of two T cell epitopes delivered as synthetic peptides by fixed macrophages. Treatment of bone marrow macrophages with inhibitors of proteinases of the metallo-, aspartic and serine proteinase families enhanced presentation