Cardiovascular and hormonal effects of pramipexole, a novel dopamine agonist.
✍ Scribed by Peters, G.R.; Francom, S.F.; Wright, C.E.
- Book ID
- 110019636
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 153 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-9236
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PHNO, a naphthoxazine compound, was investigated in animal models of central dopaminergic activity. The drug in doses of 5-300 micrograms/kg when administered subcutaneously, or transdermally, induced stereotypic behavior in rats which was blocked by haloperidol but not by reserpine pretreatment. In
## Abstract ## Objective To assess the efficacy and safety of pramipexole, a dopamine 3 receptor agonist, in patients with fibromyalgia. ## Methods In this 14‐week, single‐center, double‐blind, placebo‐controlled, parallel‐group, escalating‐dose trial, 60 patients with fibromyalgia were randomiz