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Cardiac electrophysiological actions of adenosine

✍ Scribed by Miduturu Srinivas; Yejia Song; John C. Shryock; Luiz Belardinelli

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 109 KB
Volume: 45
Category: Article
ISSN: 0272-4391
DOI: 10.1002/(sici)1098-2299(199811/12)45:3/4<420::aid-ddr43>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

Adenosine, an endogenous nucleoside, modulates heart functions via cell membrane receptors. This review focuses on the A 1 adenosine receptor-mediated electrophysiological effects on cardiac myocytes. Activation of A 1 adenosine receptors leads to reductions of heart rate, atrioventricular nodal conduction, and atrial contractile force, and to an attenuation of the effects of b-adrenergic stimulation on myocardium. The ionic mechanisms and the receptor-effector coupling systems that underly the inhibitory effects of adenosine are discussed.

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