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CARD15/NOD2 Mutations in Crohn's Disease

✍ Scribed by JEAN-PIERRE HUGOT

Book ID: 111478832
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 163 KB
Volume: 1072
Category: Article
ISSN: 0890-6564
DOI: 10.1196/annals.1326.011

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## Background: Three mutations (r702w, g908r, and 1007fs) of the card15/nod2 gene associate with crohn's disease (cd). despite a strong linkage of cd to the inflammatory bowel disease (ibd) 1 region, only 16% of the finnish cd patients carry 1 of these 3 mutations, pointing to the possibility of ye