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NOD2/CARD15 mutations and presence of granulomas in pediatric and adult Crohn's disease

✍ Scribed by Ron Shaoul; Amir Karban; Batia Weiss; Shimon Reif; Dror Wasserman; Avi Pacht; Rami Eliakim; Joram Wardi; Haim Shirin; Eitan Wine; Esther Leshinsky-Silver; Arie Levine

Book ID: 110086286
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 114 KB
Volume: 10
Category: Article
ISSN: 1078-0998
DOI: 10.1097/00054725-200411000-00003

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## Background: Three mutations (r702w, g908r, and 1007fs) of the card15/nod2 gene associate with crohn's disease (cd). despite a strong linkage of cd to the inflammatory bowel disease (ibd) 1 region, only 16% of the finnish cd patients carry 1 of these 3 mutations, pointing to the possibility of ye