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Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice

โœ Scribed by Anna Kinoshita; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Tsuyoshi Arai; Osamu Minowa; Tetsuo Noda; Susumu Nishimura; Shoji Fukushima


Book ID
108583889
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
583 KB
Volume
98
Category
Article
ISSN
1347-9032

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## Abstract Ogg1 DNA repair enzyme recognizes and excises oxidative stressโ€caused 8โ€hydroxylโ€deoxyguanosine (8โ€OHdG) from GC baseโ€pairs. Ogg1 knockout mice are phenotypically normal, but exhibit elevated levels of 8โ€OHdG in nuclear and mitochondrial DNA, as well as moderately elevated mutagenesis a