Carcinogenicity of diethylnitrosamine in vitamin-A-deficient mice

✍ Scribed by Uma Santhanam; V. S. Lautha; S. V. Bhide

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: French
• Weight: 372 KB
• Volume: 40
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910400613

✦ Synopsis

The effect of suboptimal levels of dietary vitamin A on diethylnitrosamine (DEN) carcinogenesis was studied in BALE/ c and Swiss mice. Two different dietary regimens were employed to induce vitamin A deficiency and DEN was administered by lavage at 2 dose levels: 0.6 mg/kg as a single dose and 200 mg/kg in 4 divided doses. Shark liver oil (SLO) which was the main source of vitamin A in the standard diet, was deleted in one regimen and reduced to 25% in the other. The mice maintained on the former diet were given a high dose of DEN and those on the latter diet received a low dose. In both strains the deficient mice had a greater tumour incidence than those on standard diet with a marginal reduction in the latent period. A t the low level of DEN there was shift in organotrophy, i.e. from liver in controls to lung in the vitamin-A-deficient mice of BALB/c strain. With the higher dose, lung adenomas predominated in deficient as well as control groups in both the strains. Forestomach carcinomas appeared in deficient mice and not in the controls.

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