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Carcinogenic effect of N-nitrosobis(2-hydroxypropyl)-amine in rabbits

โœ Scribed by Kondo, Hiromu; Ikeda, Tomikazu; Yoshimura, Yoshiko; Hoshimura, Hitoshi; Konishi, Yoichi


Book ID
122046278
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
263 KB
Volume
5
Category
Article
ISSN
0304-3835

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Synthesis of 14C-labeled N-nitrosobis (2
โœ R. Kupper; D. Nagel; R. Gingell; G. Brunk ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 176 KB

N-Nitrosobis(2-hydroxypropy1)amine (BHP potent pancreatic carcinogen in the Syrian golden hamster, was synthesized with the 14C-label in the 1-position of one of the propyl groups. Starting with lactic-l-14C acid, RHP was prepared utilizing a four-step reaction sequence, with an overall yield of 45%