𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 14C-labeled N-nitrosobis (2-hydroxypropyl) amine

✍ Scribed by R. Kupper; D. Nagel; R. Gingell; G. Brunk

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
176 KB
Volume
15
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

N-Nitrosobis(2-hydroxypropy1)amine (BHP potent pancreatic carcinogen in the Syrian golden hamster, was synthesized with the 14C-label in the 1-position of one of the propyl groups. Starting with lactic-l-14C acid, RHP was prepared utilizing a four-step reaction sequence, with an overall yield of 45%. Intermediate purification was not necessary.

📜 SIMILAR VOLUMES

Synthesis of 14C-labeled N-nitrosobis (2
Synthesis of 14C-labeled N-nitrosobis (2-oxopropyl) amine
✍ D. Nagel; R. Kupper 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 175 KB

## Abstract N‐Nitrosobis (2‐oxopropyl) amine (BOP), a potent and selective pancreatic carcinogen in the Syrian golden hamster was synthesized with a ^14^C label in the alpha carbon. Oxidation of 2‐hydroxypropyl‐2‐hydroxypropyl‐1‐^14^C‐amine followed by nitrosation with sodium nitrite and hydrochlor

Hypermethylation of the Dal-1 gene in lu
Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
✍ Toshifumi Tsujiuchi; Tomomi Masaoka; Eriko Sugata; Mariko Onishi; Hiromasa Fujii 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

## Abstract DAL‐1 (differentially expressed in adenocarcinoma of the lung) is an actin‐binding protein that has been shown to suppress growth in lung cancer cells. Recently, inactivation of the gene encoding DAL‐1 due to hypermethylation has been found in several human malignancies, including lung

Alterations of the Dutt1/Robo1 gene in l
Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
✍ Toshifumi Tsujiuchi; Yasutaka Sasaki; Yasuo Oka; Hiroki Kuniyasu; Masahiro Tsuts 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

## Abstract Abnormalities of tumor suppressor genes (TSGs) on chromosome 3p are known to be important for the development of human lung cancers. In the present study, we investigated alterations of the __Dutt1__/__Robo1__ gene, as a possible tumor suppressor in this region, in rat lung adenocarcino

Aberrant methylation patterns of the Ras
Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine
✍ Kyoko Shimizu; Ayumi Kato; Mayumi Shigemura; Hiromasa Fujii; Kanya Honoki; Toshi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

To clarify the involvement of the Rassf1a gene in lung carcinogenesis, we investigated the methylation status in the 5 0 upstream region of the RAS-association domain family 1, isoform A (Rassf1a) gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). Six-week-old male

Synthesis of 14C-labeled and 2H-labeled
Synthesis of 14C-labeled and 2H-labeled dibucaine
✍ Naba K. Chaudhuri 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 329 KB 👁 1 views

A synthesis of dibucaine labeled with l"C in the heterocyclic ring is described. starting with isatin and acetic anh~dride-2-~"C as shown in Scheme I. Two deutero analogs, dibucaine-d2 and dibucaine-dg, were also synthesized by the reactions shown in Scheme 11. Dibucaine-dg was synthesized by conden

A high yield synthesis of C-14-ring-labe
A high yield synthesis of C-14-ring-labeled and C-14-methyl-labeled N-methyl-N-nitrosoaniline
✍ C. J. Grandjean 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 232 KB 👁 1 views

## Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were s