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Synthesis of 14C-labeled N-nitrosobis (2-oxopropyl) amine

✍ Scribed by D. Nagel; R. Kupper

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
175 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

N‐Nitrosobis (2‐oxopropyl) amine (BOP), a potent and selective pancreatic carcinogen in the Syrian golden hamster was synthesized with a ^14^C label in the alpha carbon. Oxidation of 2‐hydroxypropyl‐2‐hydroxypropyl‐1‐^14^C‐amine followed by nitrosation with sodium nitrite and hydrochloric acid gave radiolabeled BOP in 60% yield.

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