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Carcinogen-induced chromosome breakage in Fanconi's anaemia heterozygous cells

✍ Scribed by AUERBACH, ARLEEN D.; WOLMAN, SANDRA R.

Book ID
109708166
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
390 KB
Volume
271
Category
Article
ISSN
0028-0836

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The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in lymphocyte cultures from a patient with typical Fanconi's anemia and his parents. The rate of SCEs was found to be normal. In experiments with the alkylating agent Trenimon the SCE