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Spontaneous and adenovirus type 12-induced chromosome aberrations in fanconi's anaemia fibroblasts

✍ Scribed by J. K. McDougall

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
641 KB
Volume
7
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The spontaneous aberrations which occur in cells from patients with Fanconi's anaemia have been shown to be distributed in a random manner. Adenovirus type 12‐induced chromosome aberrations are non‐random in cells from patients with Fanconi's anaemia and there is a high degree of specificity for a site on the No. 17 chromosome, as is found in cytogenetically normal human cells.

Although foci of infected cells were found in long‐term Fanconi cultures there was no evidence of viral transformation.

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The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts
✍ K. Hayashi; W. Schmid 📂 Article 📅 1975 🏛 Springer 🌐 English ⚖ 356 KB

The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in lymphocyte cultures from a patient with typical Fanconi's anemia and his parents. The rate of SCEs was found to be normal. In experiments with the alkylating agent Trenimon the SCE