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Carcinogen-induced chromosome breakage in chromosome instability syndromes

✍ Scribed by Arleen D. Auerbach; Sandra R. Wolman


Book ID
119102429
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
455 KB
Volume
1
Category
Article
ISSN
0165-4608

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Immune deficiency and chromosome fragility are hallmarks of two human diseases, ataxia telangiectasia and Nijmegen breakage syndrome. The genes mutated in these diseases, ATM and NBSl, have been cloned and there has been considerable recent progress on deciphering the function of the protein product