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Carboxylesterase inhibition and potentiation of soman toxicity

✍ Scribed by Steven D. Cohen

Book ID
104735669
Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
83 KB
Volume
49
Category
Article
ISSN
0340-5761

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πŸ“œ SIMILAR VOLUMES

Iso-OMPA-induced potentiation of soman t
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✍ Zoran Grubič; DuΕ‘an Sket; Miro Brzin πŸ“‚ Article πŸ“… 1988 πŸ› Springer-Verlag 🌐 English βš– 158 KB

Recently, the question was raised as to why iso-OMPA, generally known as a selective irreversible inhibitor of butyrylcholinesterase (BuChE), potentiates soman toxicity in rats but not in mice. Mice are known to have higher carboxylesterase (CarbE) and lower BuChE activity in plasma than rat. It cou

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Male Sprague-Dawley rats, injected with the irreversible acetylcholinesterase (AChE) inhibitor soman (pinacolyl methylphosphonofluoridate) 25 micrograms/kg sc, showed no signs of toxicity. Pretreatment with iso-OMPA (tetraisopropylpyrophosphoramide) 1 mg/kg sc 1 h before the soman administration, ca