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Role of carboxylesterases in the prevention and potentiation of N-methylcarbamate toxicity

✍ Scribed by Ramesh C. Gupta; Wolf-D. Dettbarn


Book ID
113137646
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
493 KB
Volume
87
Category
Article
ISSN
0009-2797

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Iso-OMPA-induced potentiation of soman t
✍ Zoran Grubič; DuΕ‘an Sket; Miro Brzin πŸ“‚ Article πŸ“… 1988 πŸ› Springer-Verlag 🌐 English βš– 158 KB

Recently, the question was raised as to why iso-OMPA, generally known as a selective irreversible inhibitor of butyrylcholinesterase (BuChE), potentiates soman toxicity in rats but not in mice. Mice are known to have higher carboxylesterase (CarbE) and lower BuChE activity in plasma than rat. It cou