## Abstract The synthesis of a novel unnatural carbocyclic analog of the acetylcholine esterase inhibitor galanthamine with a K~3~[Fe(CN)~6~] promoted oxidative tandem cyclization as the key step is reported.
Carbocyclic Galanthamin Analogues: 4a,5,9,10,11,12-Hexahydro-6H-benzo[b]cyclohepta[cd]benzofurans.
β Scribed by Matthias Treu; Kurt Mereiter; Christian Hametner; Johannes Froehlich; Ulrich Jordis
- Book ID
- 101939540
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 178 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
## Abstract The molecular structures of the title compounds 3 and 5 were investigated by NMR and Xβray structural methods. The NMR results suggest two equivalent halves for both molecules. The Xβray study shows an approximate mirror plane for 3 and an approximate twofold axis for a significant port
The title compound, C 25 H 20 ClN 3 O 2 ΓC 3 H 7 NO, was synthesized by the reaction of 4-chlorobenzaldehyde, 2-(5,5-dimethyl-3oxocyclohex-1-enylamino)benzoic acid and malononitrile in ethylene glycol under microwave irradiation. The dihydropyridine and pyrimidine rings both adopt boat conformations