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Carbamazepine interacts with a slow inactivation state of NaV1.8-like sodium channels

โœ Scribed by Carlos A. Cardenas; Carla G. Cardenas; Alberto J. de Armendi; Reese S. Scroggs


Book ID
116769018
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
343 KB
Volume
408
Category
Article
ISSN
0304-3940

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi