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Multiple transcripts of sodium channel SCN8A (NaV1.6) with alternative 5′- and 3′-untranslated regions and initial characterization of the SCN8A promoter

✍ Scribed by Valerie L. Drews; Andrew P. Lieberman; Miriam H. Meisler


Book ID
116981331
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
512 KB
Volume
85
Category
Article
ISSN
0888-7543

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## Abstract Voltage‐gated sodium channels play critical roles in the excitability of the brain. A decreased level of Na~v~1.1 has been identified as the cause of severe myoclonic epilepsy in infancy. In the present study, we identified the transcription start site and three 5′‐untranslated exons of