✦ LIBER ✦

Capillary GC-MS investigation of the metabolism of formyldienolone in man

✍ Scribed by Cartoni, G. P. ;Ciardi, M. ;Giarrusso, A. ;Rosati, F.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 432 KB
Volume: 14
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240141212

No coin nor oath required. For personal study only.

✦ Synopsis

This method will be useful in other areas of cancer research for determining the risks associated with the handling of cytotoxic drugs. Most importantly, the presence of trace levels of IF, CY, and their metabolites can now be related to mutagenic effects by comparing data of sister chromatid exchanges (SCE) induced by exposure of CHO cells to biological fluids containing the compounds of interest 1111. This will finally result in a definition of the "mutagenic levels" of CY, IF, and/or their metabolites in hunans.

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