Two rapid, sensitive, and specific gas chromatographic (GC) methods for the quantitative determination of quazepam (I), 7-chloro-5-(2fluorophenyl-1,3-dihydro-1 -(2,2,2-trifluoroethyl)-2H -1,4-benzodiazepine-Zthione, and its major active plasma metabolites, the 2-0x0 compound (11) and the dealkylated
Capillary gas chromatographic determination of major and minor metabolites of aromatic solvents in human urine
✍ Scribed by Korn, M. ;Wodarz, R. ;Drysch, K. ;Schmahl, F. W.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 402 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0935-6304
No coin nor oath required. For personal study only.
✦ Synopsis
Aromatic solvents are involved in manifold areas of industry and craft. Inhaled solvent vapors are a known health hazard to workers. For medical prevention and toxicological assay specific laboratory methods for urinary metabolites are necessary. An economical capillary gas chromatographic procedure is described which is suitable for routine analysis of major metabolites, sensitive for the determination of minor metabolites, and effective for the separation of chiral metabolic intermediates.
📜 SIMILAR VOLUMES
A method is described which determines aspirin and its major metabolites in human urine. The samples are specifically treated for the determination of free metabolites (all nonconjugated forms) and total metabolites (free and conjugated forms), followed by extraction through solid phase C 18 cartrid
## Abstract 1‐(__o__‐methoxyphenoxy)‐3‐isopropylamino‐2‐propanol hydrochloride (moprolol, Omeral^R^), is a new β‐adrenergic blocking agent. A gas chromatographic method for determining unchanged moprolol in human biological fluids has been developed. After solvent extraction, a bis‐trifluoroacetyl