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Candida antarctica lipase B catalyzes the regioselective esterification of ecdysteroids at the C-2 OH

✍ Scribed by Bruno Danieli; Giordano Lesma; Monica Luisetti; Sergio Riva

Book ID
104207741
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
391 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Immobilized Candida antarctica lipase B (Novozym 435) catalyzes the regioselective acylation of 20R-hydroxyecdysone (In) and its congeners 2a, 3a and 4a at the C-2 OH in high yield and purity.

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The inside cover picture shows that the wrong hand can fit into a glove in two different ways. Recognizing the incorrect fit requires different mechanisms: 1) fingers mismatched or 2) palm curl incorrect. Similarly, the wrong enantiomer can fit into an enzyme's active site in different ways and requ