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Inside Cover: Molecular Basis for the Stereoselective Ammoniolysis of N-Alkyl Aziridine-2-Carboxylates Catalyzed by Candida antarctica Lipase B (ChemBioChem 13/2009)

✍ Scribed by Jae-Hoon Park; Hyun-Joon Ha; Won Koo Lee; Tobie Généreux-Vincent; Romas J. Kazlauskas

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 416 KB
Volume: 10
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200990054

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✦ Synopsis

The inside cover picture shows that the wrong hand can fit into a glove in two different ways. Recognizing the incorrect fit requires different mechanisms: 1) fingers mismatched or 2) palm curl incorrect. Similarly, the wrong enantiomer can fit into an enzyme's active site in different ways and require different mechanisms for high enantioselectivity. For more information, see the article by R.

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Molecular Basis for the Stereoselective

Molecular Basis for the Stereoselective Ammoniolysis of N-Alkyl Aziridine-2-Carboxylates Catalyzed by Candida antarctica Lipase B

✍ Jae-Hoon Park; Hyun-Joon Ha; Won Koo Lee; Tobie Généreux-Vincent; Romas J. Kazla 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 1 views

## Abstract Candida antarctica __lipase B catalyzed the stereoselective ammoniolysis of__ N__‐alkyl aziridine‐2‐carboxylates in__ t__BuOH saturated with ammonia and yielded the (2__S__)‐aziridine‐2‐carboxamide and unreacted (2__R__)‐aziridine‐2‐carboxylate. Varying the N‐1 substituent on the azirid