Cancer predisposing missense and protein
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Sylvia De Brakeleer; Jacques De Grève; Remy Loris; Nicolas Janin; Willy Lissens;
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Article
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2010
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John Wiley and Sons
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English
⚖ 321 KB
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Fifteen years ago BRCA1 and BRCA2 were reported as high penetrant breast cancer predisposing genes. However, mutations in these genes are found in only a fraction of high risk families. BARD1 is a candidate breast cancer gene, but only a limited number of missense mutations with rather unclear patho