✦ LIBER ✦

BRCA1 mutation analysis in breast/ovarian cancer families from Greece

✍ Scribed by Irene Konstantopoulou; Christos Kroupis; Angela Ladopoulou; Alexandros Pantazidis; Dimitra Boumba; Evriklia S. Lianidou; Michael B. Petersen; Lina Florentin; Efstratios Chiotellis; George Nounesis; Eleni Efstathiou; Dimosthenis Skarlos; Christina Tsionou; George Fountzilas; Drakoulis Yannoukakos

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 40 KB
Volume: 16
Category: Article
ISSN: 1059-7794
DOI: 10.1002/1098-1004(200009)16:3<272::aid-humu17>3.0.co;2-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

BRCA1 mutation analysis in 83 Spanish br

BRCA1 mutation analysis in 83 Spanish breast and breast/ovarian cancer families

✍ Orland Díez; Joan Cortés; Montserrat Domènech; Joan Brunet; Elisabeth Del Río; C 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 142 KB 👁 1 views

A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A G G, 1240C G

BRCA1 mutations in German breast-cancer

BRCA1 mutations in German breast-cancer families

✍ Burkhard Jandrig; Klaus Grade; Susanne Seitz; Beate Waindzoch; Manuela Müller; E 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 488 KB 👁 2 views

We analyzed germline mutations of the BRCAl gene in 20 German breast/ovarian-cancer families. BRCA I mutations cosegregating with breast-cancer susceptibility were identified in 3 of these families. All mutations were found to generate a premature stop codon leading to the synthesis of truncated BRC

BRCA1-related breast cancer in Austrian

✍ Teresa M. U. Wagner; Regine A. Möslinger; Daniela Muhr; Gudrun Langbauer; Kora H 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 76 KB 👁 2 views

We identified 17 BRCA1 mutations in 86 Austrian breast and ovarian cancer families (20%) that were screened for mutations by denaturing high-performance liquid chromatography (DHPLC) and the protein truncation test (PTT). Eleven distinct mutations were detected, 4 of them (962del4, 2795del4, 3135del

Ten novel BRCA1 and BRCA2 mutations in b

Ten novel BRCA1 and BRCA2 mutations in breast and/or ovarian cancer families from northern Germany

✍ Marion Kiechle; Eva Gross; Ulrike Schwarz-Boeger; Jacobus Pfisterer; Walter Jona 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 14 KB 👁 2 views

Founder BRCA1 mutations and two novel ge

Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland

✍ Marco van der Looij; Barbara Wysocka; Izabela Brozek; Jacek Jassem; Janusz Limon 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 2 views

Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o

Mutations and alternative splicing of th

Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families

✍ Chun-Fang Xu; Julie A. Chambers; Hans Nicolai; Melissa A. Brown; Yasir Hujeirat; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 1 views

BRCA1 is a tumour suppressor gene located on chromosome band 17q21. It is estimated that mutations in the BRCA1 gene account for approximately 45% of the breast cancer families and almost all of the breast/ovarian cancer families. We have used single strand conformation polymorphism analysis, direct