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Calpain activation is upstream of caspases in radiation-induced apoptosis

✍ Scribed by Waterhouse, Nigel J; Finucane, Debra M; Green, Douglas R; Elce, John S; Kumar, Sharad; Alnemri, Emad S; Litwack, Gerald; Khanna, KumKum; Lavin, Martin F; Watters, Dianne J


Book ID
110015829
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
418 KB
Volume
5
Category
Article
ISSN
1350-9047

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Caspase activation and dependence on caspases has been observed in different paradigms of apoptotic cell death in vivo and in vitro. The present study examines the role of caspases in ionizing radiationinduced apoptosis in the developing cerebellum of rats subjected to a single dose (2-Gy β₯ rays) of