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Calothrixins, a New Class of Human DNA Topoisomerase I Poisons ⊥

✍ Scribed by Khan, Qasim A.; Lu, Jun; Hecht, Sidney M.

Book ID
120384214
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
829 KB
Volume
72
Category
Article
ISSN
0163-3864

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## Abstract Topotecan (TPT), a water‐soluble derivative of camptothecin, is a potent antitumor poison of human DNA topoisomerase I (top1) that stabilizes the cleavage complex between the enzyme and DNA. The role of the recently discovered TPT affinity to DNA remains to be defined. The aim of this w