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Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison

โœ Scribed by Cagir, Ali; Jones, Shannon H.; Gao, Rong; Eisenhauer, Brian M.; Hecht, Sidney M.


Book ID
127392308
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
54 KB
Volume
125
Category
Article
ISSN
0002-7863

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An indolocarbazole compound, NB-506, inhibits the activity of topoisomerase I by stabilizing the DNA-topoisomerase I complex (cleavable complex). NB-506 inhibited the religation step of topoisomerase I activity more potently than camptothecin or its derivative, topotecan. A cleavage assay using an e