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Calorimetric investigations of crystalline 3′,5′-cyclic nucleotides

✍ Scribed by A. M. Bryan; P. G. Olafsson

Publisher
Wiley (John Wiley & Sons)
Year
1973
Tongue
English
Weight
337 KB
Volume
12
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Differential enthalpic analysis of a series of 3′,5′‐cyclic nucleotides indicates that homolytic cleavage of the six‐membered phosphate ring occurs either immediately prior to or concurrent with decomposition of the crystal lattice. Homolysis is followed by a rapid polymerization to yield oligonucleotides. The enthalpies of these reactions have, with the exception of guanosine 3′,5′‐cyclic phosphate, almost identical values of 25 kcal/mole. The anomalous case is attributed to a more stabilized phosphate ring as a result of hydrogen bonding through the two position of the purine ring. The pair of overlapping exothermic peaks observed in each of the thermograms for cAMP and cIMP is related to the presence of two conformational arrangements within the unit cell of each compound.

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