✦ LIBER ✦

Activity of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in human cerebrospinal fluid

✍ Scribed by Dr Naren L. Banik; Lawrence B. Mauldin; Edward L. Hogan

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 273 KB
Volume: 5
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410050608

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Activity of the myelin marker enzyme 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase (CNP) was assayed in cerebrospinal fluid samples obtained from patients with multiple sclerosis (MS) and other neurological diseases. The enzyme activity was found to be elevated in acute cases of MS and reduced during remission. It was present in other demyelinating diseases, and no activity was detected in normal CSF. CNP may be released into CSF from any insult to myelin. The level of activity appears to reflect demyelination and the rate of breakdown of the myelin sheath.

📜 SIMILAR VOLUMES

Reaction of Cytidine Nucleotides with Cy

Reaction of Cytidine Nucleotides with Cyanoacetylene: Support for the Intermediacy of Nucleoside-2′,3′-cyclic Phosphates in the Prebiotic Synthesis of RNA

✍ Michael A. Crowe; John D. Sutherland 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB

Synthesis of Some 2(3H)-Benzoxazolone De

Synthesis of Some 2(3H)-Benzoxazolone Derivatives and their in-vitro Effects on Human Leukocyte Myeloperoxidase Activity

✍ Zeynep Soyer; Meral Bas; Aysun Pabuccuoglu; Varol Pabuccuoglu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 2 views

## Abstract Myeloperoxidase (MPO), a heme protein expressed by polymorphonuclear leukocytes, generates potent oxidants which are proposed to contribute to tissue damage during inflammation and certain pathogenesis such as neurodegenerative disorders. In this study, twenty ω‐[2‐oxo‐3__H__‐benzoxazol

Recognition of cell surface GD3 by monoc

Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: Expression on human T cells with transendothelial migratory activity

✍ Toshio Homma; Osamu Hosono; Satoshi Iwata; Susumu Ando; Katsutoshi Sasaki; Tatsu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 398 KB 👁 2 views

IL-4 and IL-13 regulate the induction of

IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma gondii replication in human fibroblasts activated with IFN-γ

✍ Andréa C. L. Chaves; Isabela P. Cerávolo; Juliana A. S. Gomes; Carlos L. Zani; A 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

CD16-mediated activation of phosphatidyl

CD16-mediated activation of phosphatidylinositol-3 kinase (Pl-3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc, pp36 and p85 Pl-3K subunit

✍ Cristina Cerboni; Angela Gismondi; Gabriella Palmieri; Mario Piccoli; Luigi Frat 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB 👁 1 views

Phosphatidylinositol 3-kinase (Pl-3K) plays a key role in several cellular processes, including mitogenesis, apoptosis, actin reorganization and vesicular trafficking. The molecular events involved in its activation have not been fully elucidated and several reports indicate that a key event for enz

Synthesis and Effects on the COX-1 and C

Synthesis and Effects on the COX-1 and COX-2 Activity in Human Whole Blood ex vivo of Derivatives Containing the [1]Benzothienol-[3, 2-d]pyrimidin-4-one Heterocyclic System

✍ Andrea Santagati; Giuseppe Granata; Agostino Marrazzo; Maria Santagati 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 2 views