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Cadmium Induces Phosphorylation of p53 at Serine 15 in MCF-7 Cells

✍ Scribed by Masato Matsuoka; Hideki Igisu

Book ID
115587778
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
158 KB
Volume
282
Category
Article
ISSN
0006-291X

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## Abstract Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We reported recently that roscovitine (ROSC), a potent cyclin‐dependent kinase 2 inhibitor, arrests human MCF‐7 breast cancer cells in the G~2~ phase of the cell