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Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells

✍ Scribed by M. Tampio; J. Loikkanen; P. Myllynen; A. Mertanen; K.H. Vähäkangas


Book ID
119379839
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
877 KB
Volume
178
Category
Article
ISSN
0378-4274

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Optically active isomers of a mammary carcinogen, anti-benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide, react to different extents with DNA and generate DNA adducts that differ in their stereochemistry. In the study reported here, the effect of these two enantiomers on the progress of human breast