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Effect of Distinct Anticancer Drugs on the Phosphorylation of p53 Protein at Serine 46 in Human MCF-7 Breast Cancer Cells

✍ Scribed by JÓZEFA WȨSIERSKA-GA̧DEK; MARIETA GUEORGUIEVA; IRENE HERBACEK; CARMEN RANFTLER

Book ID
111483331
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
118 KB
Volume
1095
Category
Article
ISSN
0890-6564

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Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells
✍ Józefa Węsierska-Gądek; M. Lienhard Schmitz; Carmen Ranftler 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 314 KB

## Abstract Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We reported recently that roscovitine (ROSC), a potent cyclin‐dependent kinase 2 inhibitor, arrests human MCF‐7 breast cancer cells in the G~2~ phase of the cell