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Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells

✍ Scribed by Carlos Martínez-Campa; Alicia González; Maria Dolores Mediavilla; Carolina Alonso-González; Emilio J. Sánchez-Barceló; Samuel Cos

Publisher
Springer US
Year
2005
Tongue
English
Weight
295 KB
Volume
94
Category
Article
ISSN
0167-6806

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In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr