Ca2+/Calmodulin-Dependent Protein Kinase II Mediates Platelet-Derived Growth Factor-Induced Human Hepatic Stellate Cell Proliferation
β Scribed by An Ping; Tian Yihao; Dai Jingxing; Chen Minkai; Luo Hesheng
- Book ID
- 113064281
- Publisher
- Springer US
- Year
- 2012
- Tongue
- English
- Weight
- 377 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0163-2116
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Abbreviations: HSC, hepatic stellate cells; β£-SMA, β£ smooth muscle actin; PDGF, platelet-derived growth factor; PPARβ₯, peroxisome proliferator-activated receptor β₯; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-β¬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidi
Our previous studies have shown that steady shear stress causes a transient increase of platelet-derived growth factor (PDGF) A and B chain mRNA levels in human umbilical vein endothelial cells (HUVEC). In the present study, we elucidated the signaling pathway of shear stress in HUVEC by examining t