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Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90

✍ Scribed by Yoichiro Takami; Hirofumi Uto; Masahiko Takeshita; Hisahiro Kai; Ena Akamatsu; Akihiro Moriuchi; Susumu Hasegawa; Makoto Oketani; Akio Ido; Hiroaki Kataoka; Hirohito Tsubouchi


Book ID
118088212
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
247 KB
Volume
40
Category
Article
ISSN
1386-6346

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Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t