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CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents

โœ Scribed by Charles A Omer; Nancy E Kohl


Book ID
117341542
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
264 KB
Volume
18
Category
Article
ISSN
0165-6147

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## Abstract Human cytochrome P450 (CYP)1B1 is a major enzyme for carcinogenic estrogen metabolism and involved in the metabolic activation of procarcinogens of the polycyclic aromatic hydrocarbons (PAHs). CYP1B1 is known to be expressed at a high frequency in various human cancers, but not in norma