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Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti- Trypanosoma brucei Agents

✍ Scribed by Ohkanda, Junko; Buckner, Frederick S.; Lockman, Jeffrey W.; Yokoyama, Kohei; Carrico, Dora; Eastman, Richard; de Luca-Fradley, Kate; Davies, Wendy; Croft, Simon L.; Van Voorhis, Wesley C.; Gelb, Michael H.; Sebti, Saïd M.; Hamilton, Andrew D.


Book ID
120606602
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
237 KB
Volume
47
Category
Article
ISSN
0022-2623

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Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou