C9-Iridoids from Scrophularia buergeriana
✍ Scribed by Shuang-Jun Lin; Chang-Heng Tan; Shan-Hao Jiang; Yi-Ming Li; Da-Yuan Zhu
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- German
- Weight
- 68 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Four new iridoids, buergerinins B -E (1 -4), along with three known iridoids, were isolated from the roots of Scrophularia buergeriana. Their structures were identified on the basis of spectroscopic analysis.
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## Abstract In previous work, we isolated 7 neuroprotective iridoid glycosides from the 90% MeOH fraction of __Scrophularia buergeriana__ (Scrophulariaceae). We therefore investigated the mode of action of 8‐__O‐E‐p__‐methoxycinnamoyl‐harpagide (8‐MCA‐Harp), the most potent neuroprotective iridoid,
## Abstract Bioassay‐guided fractionation of EtOH extract of the roots of __Scrophularia ningpoensis__ Hemsl. resulted in the isolation of three new iridoid glycosides, __i.e.__, 6″‐__O__‐caffeoylharpagide (**1**), 6″‐__O__‐feruloylharpagide (**2**), and 6″‐__O__‐__β__‐glucopyranosylharpagoside (**